Category: Smoking

Advances in whole aerosol approaches for in vitro e-cigarette testing by Emma Bishop

Electronic-cigarette regulation and risk assessment is a prominent and developing field, as the popularity and prevalence of this product category increases. Over the last 10 years since their emergence there have been many advances and adaptations to current in vitro testing techniques to better assess and predict absolute consumer risk. However, there are still requirements…

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Association of Respiratory Functional Indices and Smoking with Pleural Movement and Mean Lung Density Assessed Using Four-Dimensional Dynamic-Ventilation Computed Tomography in Smokers and Patients with COPD by Ryo Uemura

CONCLUSION: We demonstrated that reduced MPMV(ND/D) and GCR(ND/D) were associated with respiratory functional indices, in addition to a negative association of MPMV(ND/D) with the Brinkman index, which should be recognized when assessing local pleural adhesion on DVCT, especially for ventral pleural aspects.

Assessment of s-nitrosothiol and thiol/disulfide levels in acute coronary syndrome patients by Mehmet Murat YiğitbaşI

BACKGROUND: The level of nitric oxide (NO) is important to protect the heart from ischemic damage in acute coronary syndrome (ACS) patients. S-nitrosothiol (SNO) is a molecule that represents the main form of NO storage in the vascular structure. In addition, dynamic thiol/disulfide homeostasis (TDH) is known to play an important role in maintaining the…

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Oxidative stress-mediated EGFR activation by cigarette smoke or heated tobacco aerosol in human primary bronchial epithelial cells from multiple donors by Shugo Muratani

The epidermal growth factor receptor (EGFR) signaling pathway has essential roles in maintaining homeostasis of various tissues by regulating cell proliferation and differentiation. Deregulation of the EGFR signaling pathway is associated with various chronic diseases including chronic obstructive pulmonary disease. Cigarette smoke (CS) is known to activate EGFR, which is linked to chronic obstructive pulmonary…

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Low Escitalopram Concentrations in Patients with Depression predict Treatment Failure: A Naturalistic Retrospective Study by Xenia M Hart

INTRODUCTION: Cross sectional therapeutic drug monitoring (TDM) data mining introduces new opportunities for the investigation of medication treatment effects to find optimal therapeutic windows. Medication discontinuation has been proven useful as an objective surrogate marker to assess treatment failure. This study aimed to investigate the treatment effects of escitalopram and pharmacokinetic influences on blood levels…

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Chronic noncancer pain management: Integration of a nurse-led program in primary care by Metasebia Assefa

CONCLUSION: A nurse-led chronic pain program, initiated without extra funding, was successfully integrated into a primary care setting. Among the participating patients in the pilot project, outcomes related to pain intensity, pain interference with daily living, and opioid use were encouraging. This program could serve as a model for improving chronic noncancer pain management in…

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Clinical analysis of liver dysfunction induced by SHR-1210 alone or combined with apatinib and chemotherapy in patients with advanced esophageal squamous cell carcinoma by L Qi

Objective: To investigate the clinical characteristics of abnormal liver function in patients with advanced esophageal squamous carcinoma treated with programmed death-1 (PD-1) antibody SHR-1210 alone or in combination with apatinib and chemotherapy. Methods: Clinical data of 73 patients with esophageal squamous carcinoma from 2 prospective clinical studies conducted at the Cancer Hospital Chinese Academy of…

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Protective effects of butylated hydroxytoluene on the initiation of N-nitrosodiethylamine-induced hepatocellular carcinoma in albino rats by Sally A Fahim

Diethylnitrosamine (DEN), a hepatocarcinogen, is found in a variety of smoked and fried foods and was reported to be hepatotoxic in mice. Butylated hydroxytoluene (BHT) is a potent antioxidant used in cosmetic formulations and as a food additive and preservative. As a result, BHT was studied as a potential inhibitor in the early stages of…

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Synergetic Effect of α-ZrP Nanosheets and Nitrogen-Based Flame Retardants on Thermoplastic Polyurethane by Sensen Han

A supramolecular self-assembly method was used to prepare melamine cyanurate/α-ZrP nanosheets (MCA@α-ZrP) as a novel hybrid flame retardant for thermoplastic polyurethane (TPU). Microstructure characterization showed a uniform dispersion with strong interfacial strength of the MCA@α-ZrP hybrid within the TPU matrix, leading to simultaneous enhancements in both mechanical and fire-safety properties. The TPU/MCA@α-ZrP nanocomposite exhibited 43.1…

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Boredom Susceptibility and Quit Smoking: The Role of Anxiety Symptoms by Daniel Suárez-Castro

Boredom is one of the main reported motives for smoking. However, scarce research has examined the relationship between boredom susceptibility and abstinence achievement in treatment-seeking smokers. The aim of this study is to examine the mediating effect of anxiety symptoms in the relationship between boredom susceptibility and abstinence at the end of a smoking cessation…

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