Rare diseases refer to a group of single diseases with low incidence rates, complex pathogeneses, severe disease conditions, and rapid progression. Most rare diseases have a genetic background and may occur in childhood. Paying attention to the rare genetic diseases in children and performing early diagnosis and treatment can effectively delay the course of disease…
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Category: Quality of life
Production of mature myotubes in vitro improves the texture and protein quality of cultured pork by Xin Guan
Cultured meat technology provides a promising strategy for the production of meat protein, which is an important nutrient in daily life. Currently, there is still a lack of systematic research on the basic determinants of the texture and protein quality of cultured meat. Here we first developed a chemically defined serum-free medium consisting of serum…
An update on potential pharmacotherapies for cognitive impairment in bipolar disorder by Danica E Johnson
INTRODUCTION: Cognitive impairment is a core feature of bipolar disorder (BD) that impedes recovery by preventing the return to optimal socio-occupational functioning and reducing quality of life. Presently, there are no efficacious treatments for cognitive impairment in BD, but many pharmacological interventions are being considered as they have the potential to target the underlying pathophysiology…
Anti-calcitonin gene-related peptide monoclonal antibodies for the treatment of vestibular migraine: A prospective observational cohort study by Cinzia Valeria Russo
CONCLUSION: We show that anti-CGRP mAbs may be effective in the treatment of Vestibular Migraine. Their use should be encouraged early in the disease course to allow for a better symptom control and quality of life improvement.
Health-related quality of life among transthyretin amyloid cardiomyopathy patients by Per Eldhagen
CONCLUSIONS: KCCQ scores were lower than previously reported for patients with other heart diseases of non-ATTR CM origin. The HRQoL measures correlated well to NYHA class and NAC disease stage. The prevalence of depression appeared to be low.
Malodour from oral malignant fungating wound: sprayed metronidazole – case report by Haruka Harano
Metronidazole gel or ointment is recommended for the treatment of malodour from malignant fungating wounds. However, this medication may not settle adequately in oral lesions because its texture causes discomfort and it tends to be washed out by saliva. We report a case of malodour due to an oral lesion that was well controlled with…
Chinese expert consensus of albumin-bound paclitaxel in the treatment of breast cancer by Breast Cancer Group, Branch of Oncologist, Chinese Medical Doctor Association;
Breast cancer is the most common malignant tumor of women, which seriously threatens women’s health. Albumin-bound paclitaxel is the basic chemotherapy drug for breast cancer treatment. We can promote reasonable clinical medication and improve patients’ quality of life by standardizing chemotherapy plans, rationally optimizing treatment strategy and managing adverse reactions of albumin-bound paclitaxel. In order…
A Pilot Randomized Controlled Trial of Effectiveness of a Psychoeducational Intervention on the Management of Musculoskeletal Chronic Noncancer Pain by Sánchez-Gutiérrez Carmen
CONCLUSIONS: These findings provide promising support for the beneficial effects of psychoeducation on the intensity of noncancer chronic musculoskeletal pain. Based on the results, future randomized controlled trials are needed.
Rapid efficacy of anifrolumab across multiple subtypes of recalcitrant cutaneous lupus erythematosus parallels changes in discrete subsets of blood transcriptomic and cellular biomarkers by Lucy M Carter
CONCLUSIONS: These data indicate rapid efficacy of anifrolumab in DLE and rituximab-resistant CLE. Response is associated with suppression of a subset of ISGs and decline in intermediate monocytes. Suppression of all ISGs or the wider SLE blood transcriptome is not required for response.
Psychosocial Experiences of Cancer Survivors and their Caregivers in sub-Saharan Africa: A Synthesis of Qualitative Studies by Ashley Leak Bryant
CONCLUSION: Findings echo need for individuals with cancer and their caregivers. Healthcare professionals are an essential resource for information and support services that can be tailored to individuals need. This synthesis highlighted caregiver stress and stressors from the community that could impact care of individuals with cancer. A holistic approach is needed that incorporates professional…
Social Media Use and Depression in Older Adults: A Systematic Review by Ariz Amoroso Guzman
Social media has become an integral part of everyday life and revolutionized how older adults communicate and interact with others. The aim of the current review was to identify and synthesize quantitative studies addressing the potential relationship between social media use and depression in older adults. Medline, CINAHL, and PsycINFO databases were used to identify…
Consumer Survey on Hearing Aid Benefit and Satisfaction by Larissa Bannon
CONCLUSIONS: The results highlight importance of good hearing aid outcomes (quality, fit/comfort, and battery life) for benefit and satisfaction ratings. Professionals who fit hearing aids should strive to focus on achieving these outcomes and researchers should strive to explain the remaining variability in ratings of benefit and satisfaction.
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