Category: Pain

The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts the Analgesic and Sedative Effects on Mice by Xingyun Chai

The heartwood of Syringa oblata Lindl. (SO) is one of Mongolian folk medicine to treat insomnia and pain, but related pharmacological evaluation and mechanism of action remains unclear. In the present study, the locomotor activity test and the threshold dose of pentobarbital sodium induced sleep test in mice were used to evaluate the sedative effect…

Read the full article

Comparative Efficacy of the Stromal-Vascular Fraction Cells of Lipoaspirate and Hyaluronic Acid in the Treatment of Gonarthrosis: Results of an Interim Analysis by E Ya Shevela

The use of cell technologies, in particular the stromal-vascular fraction of adipose tissue, is a new direction in the treatment of osteoarthritis of the weight-bearing joints. Stromal-vascular fraction cells have anti-inflammatory and immunomodulatory effects and are able to differentiate into connective tissue cells, including cartilage, tendons, and ligaments. Our clinical study showed the safety and…

Read the full article

A cost-utility analysis between decompression only and fusion surgery for elderly patients with lumbar spinal stenosis and sagittal imbalance by Young Il Won

Lumbar spinal stenosis (LSS) and sagittal imbalance are relatively common in elderly patients. Although the goals of surgery include both functional and radiological improvements, the criteria of correction may be too strict for elderly patients. If the main symptom of patients is not forward-stooping but neurogenic claudication or pain, lumbar decompression without adding fusion procedure…

Read the full article

The Efficacy of Cryogenic Plasma Tonsillectomy in the Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome in Children: A Meta-Analysis by Zhiqing Liu

The objective of this meta-analysis is to investigate the clinical efficacy of cryogenic plasma tonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSAHS) in children. The literature search was conducted through China National Knowledge Infrastructure (CNKI), Wanfang Database, Embase, PubMed, and Web of Science databases. The search was from the establishment of each database to June 2022.…

Read the full article

Keratinocyte TLR2 and TLR7 contribute to chronic itch through pruritic cytokines and chemokines in mice by Zhi-Hong Wang

Although neuronal Toll-like receptors (TLRs) (e.g., TLR2, TLR3, and TLR7) have been implicated in itch sensation, the roles of keratinocyte TLRs in chronic itch are elusive. Herein, we evaluated the roles of keratinocyte TLR2 and TLR7 in chronic itch under dry skin and psoriasis conditions, which was induced by either acetone-ether-water treatment or 5% imiquimod…

Read the full article

Slow and Steady But Not Related to HIV Stigma: Physical Activity in South Africans Living with HIV and Chronic Pain by Antonia Wadley

HIV stigma may influence physical activity in people living with HIV (PLWH) and chronic pain. We prospectively examined the relationship between stigma, activity and chronic pain in a convenience sample of PLWH initiating antiretroviral therapy in an inner-city clinic in Johannesburg, South Africa. Participants wore accelerometers to measure daily duration and intensity of activity for…

Read the full article

Selective electrical stimulation of low versus high diameter myelinated fibers and its application in pain relief: a modeling study by Mohsen Kamelian Rad

Electrical stimulation of peripheral nerve fibers has always been an attractive field of research. Due to the higher activation threshold, the stimulation of small fibers is accompanied by the stimulation of larger ones. It is therefore necessary to design a specific stimulation theme in order to only activate narrow fibers. There is evidence that stimulating…

Read the full article

Spinal cord stimulation in chronic pain treatment – first experiences in Bosnia and Herzegovina by Tatjana Bućma

Aim To describe results of spinal cord stimulation technique when the conventional multidisciplinary treatment of neuropathic or mixed pain failed. Methods The research was conducted at the Institute for Physical Medicine and Rehabilitation “Dr. Miroslav Zotović”, Banjaluka. Ten patients, who had chronic pain resistant to other therapeutic options and a failed back surgery, were sent…

Read the full article

Post-traumatic instability of the first metatarsophalangeal joint: a novel surgical technique of capsular reconstruction in a young kickboxer by Gianni Caizzi

Aim To report a novel surgical technique of capsular reconstruction of post-traumatic instability of the first metatarsophalangeal joint (MTPJ). Methods The clinical case is related to a 24-year-old male athlete whose clinical symptoms began with pain and spontaneous dislocation of the left first MTPJ during a kickboxing fight. He received conservative treatment (cryotherapy and rest)…

Read the full article