Health Technol Assess. 2023 Mar;27(3):1-113. doi: 10.3310/JHWE4771. ABSTRACT BACKGROUND: Female genital mutilation is an important UK health-care challenge. There are no health benefits of female genital mutilation, and it is associated with lifelong physical, psychological and sexual impacts. The annual cost to the NHS to care for survivors is £100M. Deinfibulation may improve the health…
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Category: Surgery
Combi-TED: a new trial testing Tedopi® with docetaxel or nivolumab in metastatic non-small-cell lung cancer progressing after first line by Lorenza Landi
Future Oncol. 2023 Mar 22. doi: 10.2217/fon-2022-0913. Online ahead of print. ABSTRACT Despite the positive results obtained by first-line chemoimmunotherapy in patients with metastatic non-small-cell lung cancer (NSCLC), only a few second-line options are available after disease progression. Combi-TED is a phase II international study that will assess the efficacy of Tedopi®, a cancer vaccine,…
Anaesthetic peripheral nerve blocks for a total knee replacement revision due to infection in a patient with symptomatic chronic coronary syndrome: A case report by Marta R Pires
J Perioper Pract. 2023 Mar 22:17504589231159196. doi: 10.1177/17504589231159196. Online ahead of print. ABSTRACT This report aims to describe the perioperative management of a high-risk cardiovascular patient proposed for urgent total knee replacement revision. We discuss the use of peripheral nerve blocks and its impact on haemodynamic stability and clinical outcomes, including major cardiovascular adverse events…
Focal tonic seizures with asymmetrical posturing could allow voluntary movements: a lesson to not be misled for a non-epileptic event by Mitsumasa Fukuda
Epileptic Disord. 2023 Mar 22. doi: 10.1002/epd2.20047. Online ahead of print. ABSTRACT This report documents the clinical features of supplementary motor area seizures with voluntary movements in two patients. The first case describes a 13-year-old boy with a 2-year history of nocturnal seizures, characterized by an asymmetrical brief tonic posture followed by bilateral rapid hand…
Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis by Wei Wang
ACS Chem Neurosci. 2023 Mar 22. doi: 10.1021/acschemneuro.2c00691. Online ahead of print. ABSTRACT PTEN-induced kinase 1 (PINK1)-mediated mitophagy and caspase-1/gasdermin D canonical pyroptosis pathways have been implicated in the pathogenesis of postoperative cognitive dysfunction (POCD). However, gasdermin E (GSDME), another recently identified executioner of pyroptosis that can be specifically cleaved by caspase-3, is highly expressed…
Increased risk of cutaneous immune-related adverse events in patients treated with talimogene laherparepvec and immune checkpoint inhibitors: A multi-hospital cohort study by Bonnie W Leung
J Am Acad Dermatol. 2023 Mar 19:S0190-9622(23)00268-2. doi: 10.1016/j.jaad.2023.02.017. Online ahead of print. ABSTRACT BACKGROUND: Previous studies have shown that combining immune checkpoint inhibitors (ICIs) with talimogene laherparepvec (TVEC) may improve antitumor responses. However, the risk of developing cutaneous immune-related adverse events (cirAEs) in patients treated with ICI and TVEC has not been studied. OBJECTIVE:…
Reply: The best patient for the operation, or the best operation for the patient? by Martha M O McGilvray
J Thorac Cardiovasc Surg. 2023 Mar 19:S0022-5223(23)00179-4. doi: 10.1016/j.jtcvs.2023.02.020. Online ahead of print. NO ABSTRACT PMID:36944563 | DOI:10.1016/j.jtcvs.2023.02.020
Postoperative Leptomeningeal Dissemination After Brain Metastasis Resection: Recent Insights and Future Directions by Ramin A Morshed
World Neurosurg. 2023 Feb 28:S1878-8750(23)00273-5. doi: 10.1016/j.wneu.2023.02.124. Online ahead of print. NO ABSTRACT PMID:36944567 | DOI:10.1016/j.wneu.2023.02.124
Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report by Ayako Sumii
Am J Case Rep. 2023 Mar 21;24:e939369. doi: 10.12659/AJCR.939369. ABSTRACT BACKGROUND Hemophagocytic syndrome (HPS) is a rare syndrome characterized by abnormal activation of histiocytes and hemophagocytosis. We report the clinical management of recurrent HPS following 2 cesarean sections in the same patient. CASE REPORT A 33-year-old primiparous mother presented during her second trimester of pregnancy,…
Remote effects of temporal lobe epilepsy surgery: long-term morphological changes after surgical resection by T Campbell Arnold
Epilepsia Open. 2023 Mar 21. doi: 10.1002/epi4.12733. Online ahead of print. ABSTRACT OBJECTIVE: Epilepsy surgery is an effective treatment for drug-resistant patients. However, how different surgical approaches affect long-term brain structure remains poorly characterized. Here we present a semi-automated method for quantifying structural changes after epilepsy surgery and compare the remote structural effects of two…
Parental Caregiver Expectations and Satisfaction Following Hip Reconstruction and Spinal Fusion in Children With Cerebral Palsy by David Geyer
Orthop Nurs. 2023 Mar-Apr 01;42(2):94-102. doi: 10.1097/NOR.0000000000000928. ABSTRACT Children with severe (Gross Motor Function Classification System [GMFCS] IV-V) cerebral palsy (CP) exhibit profound physical and developmental impairments and require assistance for all activities of daily living. No curative treatments exist although surgical procedures to correct underlying hip and spine deformities can improve their quality of…
Neonate, Infant, Childhood, and Adolescent Epilepsy Syndromes by Walt Banoczi
Neurodiagn J. 2023 Mar 21:1-36. doi: 10.1080/21646821.2023.2172951. Online ahead of print. ABSTRACT Epilepsy syndromes are defined either by a specific set of symptoms or by the area of the brain where the seizures originate. Some of the symptoms include types of seizures and age of seizure onset. Other symptoms include the frequency and severity of…
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