Category: Nuclear medicine

Design and Synthesis of A Mitochondrial-Targeted JNK Inhibitor and Its Protective Effect on Parkinson’s Disease Phenotypes by Zhiqiang Zhou

C-Jun N-terminal kinase (JNK) is a key mediator involved in a variety of physiological processes. JNK activation is regulated in a complex manner by upstream kinases and phosphatases and plays an important role in physiological processes such as the immune response and neuronal function. Therefore, JNK has become a therapeutic target for neurodegenerative diseases, ankylosing…

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Validation of Monte Carlo simulated absorbed-dose-to-water inside a custom SPECT/CT phantom using active and passive dosimeters: a feasibility study using99mTc by Andrew Bertinetti

This project aims to provide a novel method for performing dosimetry measurements on TRT radionuclides using a custom-made SPECT/CT compatible phantom, common active and passive detectors, and Monte Carlo simulations. In this work we present a feasibility study using 99mTc for a novel approach to obtaining reproducible measurements of absorbed dose to water from radionuclide…

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18F-PSMA-1007 salivary gland dosimetry: comparison between different methods for dose calculation and assessment of inter- and intra-patient variability by Daniele Pistone

Simplified calculation approaches and geometries are usually adopted for salivary glands (SGs) dosimetry. Our aims were i) to compare different dosimetry methods to calculate SGs absorbed doses (ADs) following [18F]-PSMA-1007 injection, and ii) to assess the AD variation across patients and single SG components. Approach: Five patients with prostate cancer underwent sequential PET/CT acquisitions of…

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Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis by Luxi Zou

The correlation between ubiquitin-editing enzyme A20 and E3 ubiquitin ligase ring finger protein (RNF) 168 has been reported to be critical for repair of DNA damage. This study aimed to evaluate the potential role of this regulatory interaction in the pathogenesis of lupus nephritis (LN). The expression of RNF168 and A20 was measured in the…

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Nicaraven protects against endotoxemia-induced inflammation and organ injury through modulation of AMPK/Sirt1 signaling in macrophages by Duoduo Zha

Endotoxemia is a disease characterized by systemic inflammatory responses and organ injury caused by lipopolysaccharide (LPS) infection, with high mortality. Nicaraven (AVS), a potent hydroxyl radical scavenger, has been proven to regulate the inflammatory response in tumors. To investigate the protective effects and mechanisms of AVS in endotoxemia, mice were injected intraperitoneally with LPS to…

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The performance of digital chest radiographs in the detection and diagnosis of pulmonary nodules and the consistency among readers by M Liang

Objective: To investigate the detection and diagnostic efficacy of chest radiographs for ≤30 mm pulmonary nodules and the factors affecting them, and to compare the level of consistency among readers. Methods: A total of 43 patients with asymptomatic pulmonary nodules who consulted in Cancer Hospital, Chinese Academy of Medical Sciences from 2012 to 2014 and…

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