Objective: Genome-wide association studies (GWASs) have identified single nucleotide polymorphisms (SNPs) in chr11p15.5 region associated with asthma and idiopathic interstitial pneumonias (IIPs). We sought to identify functional genes for asthma by combining SNPs and mRNA expression in bronchial epithelial cells (BEC) in the Severe Asthma Research Program (SARP). Methods: Correlation analyses of mRNA expression of…
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Category: Internal medicine
Metastatic pheochromocytoma and paraganglioma: Somatostatin receptor 2 expression, genetics and therapeutic responses by Alessa Fischer
CONCLUSIONS: SSTR2 expression was independently associated with SDHB/SDHx mutations and metastatic disease. We confirm a high disease control rate of somatostatin receptor-based therapies in metastatic PPGLs.
Comparative evaluation between external jugular and internal jugular venous catheterization through landmark technique by Hitesh Khanna
CONCLUSION: Anaesthetists should rethink alternate routes for the insertion of central vein cannulation. The external jugular cannulation route is one of them.
Targeted therapies in advanced biliary tract cancers-a narrative review by Michael LaPelusa
CONCLUSIONS: Targeted agents can improve survival in patients with advanced BTCs and have substantially increased the number of potential therapeutic options in patients with refractory disease. The therapeutic landscape of targeted therapies for patients with advanced BTCs continues to evolve based on improvements in detection of genomic alterations.
A critical review of methotrexate clinical interactions: role of transporters by Fatemeh Jafari
INTRODUCTION: Methotrexate (MTX) is an anti-folate and immunosuppressive drug prescribed for various malignancies and immune diseases. However, delayed elimination of MTX associated with concomitant use of some medications can lead to severe and life-threatening adverse effects.
US Food and Drug Administration regulatory reviewer disagreements and postmarket safety actions among new therapeutics by Ashley Eadie
CONCLUSIONS: This investigation of regulatory reviewer disagreements and postmarket safety actions among new therapeutics suggests that disagreements among regulatory reviewers may lead to important pre-emptive actions, potentially mitigating the need for postmarket safety actions to be taken.
The representational similarity between visual perception and recent perceptual history by Junlian Luo
From moment to moment, the visual properties of objects in the world fluctuate due to external factors like ambient lighting, occlusion and eye movements, and internal (proximal) noise. Despite this variability in the incoming information, our perception is stable. Serial dependence, the behavioral attraction of current perceptual responses towards previously seen stimuli, may reveal a…
Lack of structural brain alterations associated with insomnia: findings from the ENIGMA-Sleep Working Group by Antoine Weihs
Existing neuroimaging studies have reported divergent structural alterations in insomnia disorder (ID). In the present study, we performed a large-scale coordinated meta-analysis by pooling structural brain measures from 1085 subjects (mean [SD] age 50.5 [13.9] years, 50.2% female, 17.4% with insomnia) across three international Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)-Sleep cohorts. Two sites recruited patients…
Characteristics and trends of publications in the European Journal of Internal Medicine by Thomas Gamstaetter
No abstract
The role of ultrasound synovitis scores for patients who are at risk of rheumatoid arthritis by Tsai-Hung Yen
CONCLUSION: Total GS score may differentiate patients at risk for RA from non-RA patients, while total PD score may differentiate patients with RA from those who are at risk for RA.
“It Is So Easy For Them to Dismiss”: A Phenomenological Study of Cancer Survivors with Chronic Cancer-Related Pain by Katie Fitzgerald Jones
Background: For many cancer survivors post-cure, chronic pain is a devastating complication of cancer treatment. The prevalence of chronic pain among cancer survivors is double that of the general population. However, little is known about the pain experience of cancer survivors who may have a different perspective than people with advanced cancer or people with…
Response by Tabák et al to Letters Regarding Article, “Risk of Macrovascular and Microvascular Disease in Diabetes Diagnosed Using Oral Glucose Tolerance Test With and Without Confirmation by Hemoglobin A1c: The Whitehall II Cohort Study” by Adam G Tabák
No abstract
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