Aim: Because of the severe morbidity and mortality of gastric cancer, discovering new candidate drugs has been an urgent issue. The close association between histone deacetylase 6 (HDAC6) and gastric cancer makes the development of HDAC6-targeted anti-gastric cancer drugs a viable idea. Methods & results: Carbenoxolone disodium was identified as a novel HDAC6 inhibitor. Cellular…
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Category: Cancer
Combi-TED: a new trial testing Tedopi® with docetaxel or nivolumab in metastatic non-small-cell lung cancer progressing after first line by Lorenza Landi
Despite the positive results obtained by first-line chemoimmunotherapy in patients with metastatic non-small-cell lung cancer (NSCLC), only a few second-line options are available after disease progression. Combi-TED is a phase II international study that will assess the efficacy of Tedopi^(®), a cancer vaccine, combined with either docetaxel or nivolumab and compared with docetaxel monotherapy in…
Risk of developing a second primary melanoma after a first primary melanoma in a population-based Australian cohort by Yuan Ni
No abstract
The invalidity of and Alternative to Linear Quadratic Model as a Predictive Model for Post-Irradiation Cell Survival by Heng Li
The linear-quadratic (LQ) model has been the dominant tool in preclinical radiobiological modeling of cell survival as a function of dose. However, as a second-order polynomial approximation, it suffers from two well-known pitfalls: non-monotonic behavior and poor extrapolation. This study examined the raw data of 253 sets of photon and 943 sets of the ion…
KRAS G12C mutation: from black sheep to key player in pancreatic cancer treatment by Rebecca Ibrahim
No abstract
Differential Prognostic Value of Extrarenal Involvement in Patients With Non-Metastatic Renal Cell Cancer by Giacomo Musso
CONCLUSION: The concurrent presence of ≥ 2 pT3a features is associated to a higher risk of distant progression, relapse and cancer specific mortality, implying potential role for adjuvant therapy or a more stringent follow-up. Moreover, perirenal fat invasion is associated with worse CSS compared to other pT3a patterns taken alone.
Concordance of reflectance confocal microscopy and gene expression profiling for melanocytic lesions with uncertain malignant potential: A case series by Christian Gronbeck
For a small yet significant proportion of melanocytic lesions, histopathologic analysis may be unable to definitively evaluate malignant potential. These cases may signify a specific need for newer ancillary diagnostic technologies, including in vivo reflectance confocal microscopy (RCM) and gene expression profiling (GEP), both of which are highly sensitive in the diagnosis of melanoma. We…
Lymphomatoid papulosis with DUSP22-IRF4 rearrangement: A case report and literature review by Na Niu
Lymphomatoid papulosis (LyP) with DUSP22-IRF4 rearrangement is a rare, recently described variant of LyP histopathologically characterized by a biphasic growth pattern, with epidermotropic small-to-medium-sized atypical T-cells and dermal large and transformed T-cells diffusely expressing CD30. LyP with DUSP22-IRF4 rearrangement can mimic other cutaneous lymphoproliferative disorders, particularly primary cutaneous anaplastic large cell lymphoma (PCALCL) or transformed…
Social Support and Childhood Cancer Survivors: A Systematic Review (2006-2022) by Avril Deegan
CONCLUSIONS: Future studies of social support for child and adolescent cancer survivors need to address these shortcomings to help inform care and support interventions promoting social support in survivors. This article is protected by copyright. All rights reserved.
Psychosocial Experiences of Cancer Survivors and their Caregivers in sub-Saharan Africa: A Synthesis of Qualitative Studies by Ashley Leak Bryant
CONCLUSION: Findings echo need for individuals with cancer and their caregivers. Healthcare professionals are an essential resource for information and support services that can be tailored to individuals need. This synthesis highlighted caregiver stress and stressors from the community that could impact care of individuals with cancer. A holistic approach is needed that incorporates professional…
Correction: Increased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma by Yonghao Zhan
No abstract
Correction: Annexin A13 promotes tumor cell invasion in vitro and is associated with metastasis in human colorectal cancer by Guozhong Jiang
No abstract
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