Aim: Because of the severe morbidity and mortality of gastric cancer, discovering new candidate drugs has been an urgent issue. The close association between histone deacetylase 6 (HDAC6) and gastric cancer makes the development of HDAC6-targeted anti-gastric cancer drugs a viable idea. Methods & results: Carbenoxolone disodium was identified as a novel HDAC6 inhibitor. Cellular…
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Category: Disorders and diseases
Risk of developing a second primary melanoma after a first primary melanoma in a population-based Australian cohort by Yuan Ni
No abstract
Combi-TED: a new trial testing Tedopi® with docetaxel or nivolumab in metastatic non-small-cell lung cancer progressing after first line by Lorenza Landi
Despite the positive results obtained by first-line chemoimmunotherapy in patients with metastatic non-small-cell lung cancer (NSCLC), only a few second-line options are available after disease progression. Combi-TED is a phase II international study that will assess the efficacy of Tedopi^(®), a cancer vaccine, combined with either docetaxel or nivolumab and compared with docetaxel monotherapy in…
The invalidity of and Alternative to Linear Quadratic Model as a Predictive Model for Post-Irradiation Cell Survival by Heng Li
The linear-quadratic (LQ) model has been the dominant tool in preclinical radiobiological modeling of cell survival as a function of dose. However, as a second-order polynomial approximation, it suffers from two well-known pitfalls: non-monotonic behavior and poor extrapolation. This study examined the raw data of 253 sets of photon and 943 sets of the ion…
KRAS G12C mutation: from black sheep to key player in pancreatic cancer treatment by Rebecca Ibrahim
No abstract
Antidepressant Effects of Psilocybin in the Absence of Psychedelic Effects by Joshua D Rosenblat
No abstract
Global Mental Health Movement: Need for a cultural perspective by Nidhi Sinha
The present commentary reviews the goals and differing positions on the Movement for Global Mental Health (GMH), with a distinct emphasis on the cultural differences in the understanding of the aetiology of mental health issues. The proponents and advocates of GMH support its intentions and primary agenda of scaling up mental health services, especially in…
Digital cognitive behaviour therapy for insomnia in individuals with self-reported insomnia and chronic fatigue: A secondary analysis of a large scale randomized controlled trial by Lina Stålesen Ramfjord
Insomnia is associated with fatigue, but it is unclear whether response to cognitive behaviour therapy for insomnia is altered in individuals with co-occurring symptoms of insomnia and chronic fatigue. This is a secondary analysis using data from 1717 participants with self-reported insomnia in a community-based randomized controlled trial of digital cognitive behaviour therapy for insomnia…
Ultrasonographic/regional muscle measurements for diagnosing sarcopenia in older adults with and without dementia by Zekeriya Ülger
BACKGROUND: Sarcopenia and dementia are growing concerns among older adults that muscle and brain atrophy may cooccur. We aimed to compare the age-related loss of muscle mass by using ultrasound (US), and skeletal muscle mass index (SMI) by bioelectrical impedance analysis in older adults with and without dementia.
Clinical features of autoimmune encephalitis secondary to epidemic encephalitis B in 5 children by Li-Fang Song
CONCLUSIONS: EEB can induce AE, with anti-N-methyl-D-aspartate receptor encephalitis as the most common disease. The symptoms in the AE stage are similar to those of classical anti-N-methyl-D-aspartate receptor encephalitis. Immunotherapy is effective for children with AE secondary to EEB, and the prognosis might be related to neurological dysfunction in the acute phase of EEB.
Cross-subject classification of depression by using multiparadigm EEG feature fusion by Jianli Yang
CONCLUSION: The multiparadigm feature fusion method proposed in this paper can effectively improve the accuracy of depression classification. It was proved that eyes open and eyes closed EEG have complementary information, which was benefit for the cross-subject classification of depression. It provides new ideas for depression classification in clinics.
Readability of publicly available mental health information: A systematic review by Laura Boutemen
CONCLUSION: With the recommended readability level for health communication set at sixth grade, most publicly available information about mental disorders uses vocabulary and sentence structure that is too complex for the general public. Mixed evidence indicated that accessibility issues are also problematic.
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