Category: Disorders and diseases

Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6 by Zhiyu Song

Aim: Because of the severe morbidity and mortality of gastric cancer, discovering new candidate drugs has been an urgent issue. The close association between histone deacetylase 6 (HDAC6) and gastric cancer makes the development of HDAC6-targeted anti-gastric cancer drugs a viable idea. Methods & results: Carbenoxolone disodium was identified as a novel HDAC6 inhibitor. Cellular…

Read the full article

Combi-TED: a new trial testing Tedopi® with docetaxel or nivolumab in metastatic non-small-cell lung cancer progressing after first line by Lorenza Landi

Despite the positive results obtained by first-line chemoimmunotherapy in patients with metastatic non-small-cell lung cancer (NSCLC), only a few second-line options are available after disease progression. Combi-TED is a phase II international study that will assess the efficacy of Tedopi^(®), a cancer vaccine, combined with either docetaxel or nivolumab and compared with docetaxel monotherapy in…

Read the full article

The invalidity of and Alternative to Linear Quadratic Model as a Predictive Model for Post-Irradiation Cell Survival by Heng Li

The linear-quadratic (LQ) model has been the dominant tool in preclinical radiobiological modeling of cell survival as a function of dose. However, as a second-order polynomial approximation, it suffers from two well-known pitfalls: non-monotonic behavior and poor extrapolation. This study examined the raw data of 253 sets of photon and 943 sets of the ion…

Read the full article

Digital cognitive behaviour therapy for insomnia in individuals with self-reported insomnia and chronic fatigue: A secondary analysis of a large scale randomized controlled trial by Lina Stålesen Ramfjord

Insomnia is associated with fatigue, but it is unclear whether response to cognitive behaviour therapy for insomnia is altered in individuals with co-occurring symptoms of insomnia and chronic fatigue. This is a secondary analysis using data from 1717 participants with self-reported insomnia in a community-based randomized controlled trial of digital cognitive behaviour therapy for insomnia…

Read the full article

Clinical features of autoimmune encephalitis secondary to epidemic encephalitis B in 5 children by Li-Fang Song

CONCLUSIONS: EEB can induce AE, with anti-N-methyl-D-aspartate receptor encephalitis as the most common disease. The symptoms in the AE stage are similar to those of classical anti-N-methyl-D-aspartate receptor encephalitis. Immunotherapy is effective for children with AE secondary to EEB, and the prognosis might be related to neurological dysfunction in the acute phase of EEB.