Category: Vaccines

Measles in non-human primates by Dmitriy I Dogadov

It is six decades since the measles vaccine was first introduced, and yet we continue to see frequent outbreaks of this disease occurring all over the world. Many non-human primate (NHP) species, including apes, are susceptible to the measles virus. Spontaneous measles outbreaks have been described in a number of zoos and primate centers worldwide.…

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Perinatal mental health and COVID-19: Navigating a way forward by Katharine A Smith

The COVID-19 pandemic and its aftermath have increased pre-existing inequalities and risk factors for mental disorders in general, but perinatal mental disorders are of particular concern. They are already underdiagnosed and undertreated, and this has been magnified by the pandemic. Access to services (both psychiatric and obstetric) has been reduced, and in-person contact has been…

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A COVID-19 model incorporating variants, vaccination, waning immunity, and population behavior by Zachary LaJoie

Vaccines for COVID-19 have allowed countries to combat the spread of the disease. However, new variants have resulted in significant spikes in cases and raised severe health and economic concerns. We present a COVID-19 model to predict coupled effects of vaccine multiple-dose roll-out strategies, vaccine efficacy, waning immunity, population level of caution, sense of safety,…

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Early CD4+ T cell responses induced by the BNT162b2 SARS-CoV-2 mRNA vaccine predict immunological memory by Jie Bai

Longitudinal studies have revealed large interindividual differences in antibody responses induced by SARS-CoV-2 mRNA vaccines. Thus, we performed a comprehensive analysis of adaptive immune responses induced by three doses of the BNT162b2 SARS-CoV-2 mRNA vaccines. The responses of spike-specific CD4^(+) T cells, CD8^(+) T cells and serum IgG, and the serum neutralization capacities induced by…

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2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales by Jens H Kuhn

In March 2022, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by two new families (bunyaviral Discoviridae and Tulasviridae), 41 new genera, and 98 new species. Three hundred forty-nine species were renamed and/or moved. The accidentally…

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Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination by Constantin Schwab

Cases of myocarditis, diagnosed clinically by laboratory tests and imaging have been described in the context of mRNA-based anti-SARS-CoV-2 vaccination. Autopsy-based description of detailed histological features of vaccine-induced myocarditis is lacking. We describe the autopsy findings and common characteristics of myocarditis in untreated persons who received anti-SARS-CoV-2 vaccination. Standardized autopsies were performed on 25 persons…

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