Category: CoViD

Alterations of the fecal microbiota in relation to acute COVID-19 infection and recovery by Yue Sandra Yin

People with acute COVID-19 due to SARS-CoV-2 infection experience a range of symptoms, but major factors contributing to severe clinical outcomes remain to be understood. Emerging evidence suggests associations between the gut microbiome and the severity and progression of COVID-19. To better understand the host-microbiota interactions in acute COVID-19, we characterized the intestinal microbiome of…

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Comparison of machine learning methods with logistic regression analysis in creating predictive models for risk of critical in-hospital events in COVID-19 patients on hospital admission by Aaron W Sievering

CONCLUSIONS: Although the LR and ML models analysed showed no strong differences in performance and the most influencing predictors for COVID-19-related event prediction, our results indicate a predictive benefit from taking account for non-linear predictor-to-event relationships and effects. Future efforts should focus on leveraging data-driven ML technologies from static towards dynamic modelling solutions that continuously…

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Impact of good governance, economic growth and universal health coverage on COVID-19 infection and case fatality rates in Africa by Bereket Gebremichael

CONCLUSIONS: The findings indicate that good governance practices, favourable economic indicators and UHC have a bearing on COVID-19 infection rate and CFR. Effective health system response through a primary healthcare approach and progressively taking measures to grow their economy and increase funding to the health sector to mitigate the risk of similar future pandemics would…

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A year of experience with COVID-19 in patients with cancer: A nationwide study by Mina Khosravifar

CONCLUSION: Given the immunocompromised state of patients with malignancy and their vulnerability to Covid-19 complications, collecting data on the comorbidities and their effects on the disease outcome can build on a better clinical view and help clinicians make decisions to manage these cases better; for example, determining special clinical care, especially in the shortage of…

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A COVID-19 model incorporating variants, vaccination, waning immunity, and population behavior by Zachary LaJoie

Vaccines for COVID-19 have allowed countries to combat the spread of the disease. However, new variants have resulted in significant spikes in cases and raised severe health and economic concerns. We present a COVID-19 model to predict coupled effects of vaccine multiple-dose roll-out strategies, vaccine efficacy, waning immunity, population level of caution, sense of safety,…

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Early CD4+ T cell responses induced by the BNT162b2 SARS-CoV-2 mRNA vaccine predict immunological memory by Jie Bai

Longitudinal studies have revealed large interindividual differences in antibody responses induced by SARS-CoV-2 mRNA vaccines. Thus, we performed a comprehensive analysis of adaptive immune responses induced by three doses of the BNT162b2 SARS-CoV-2 mRNA vaccines. The responses of spike-specific CD4^(+) T cells, CD8^(+) T cells and serum IgG, and the serum neutralization capacities induced by…

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2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales by Jens H Kuhn

In March 2022, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by two new families (bunyaviral Discoviridae and Tulasviridae), 41 new genera, and 98 new species. Three hundred forty-nine species were renamed and/or moved. The accidentally…

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