The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and males, and functions associated with brain lateralization such as language skills are appearing. Diffusion tensor imaging (DTI)…
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Category: Age
Improving the Rate of Delayed Cord Clamping in Preterm Infants: A Quality Improvement Project by Shannon Chan
CONCLUSION: Using core quality improvement methodology, a multidisciplinary team implemented a series of targeted interventions which was associated with an increased rate of DCC in early preterm infants.
Effect of breastfeeding on immune function in infants with human cytomegalovirus infection by Peng-Kai Fan
CONCLUSIONS: Breastfeeding with HCMV does not affect the immune function of infants with HCMV infection.
Efficacy of noninvasive high-frequency oscillatory ventilation versus nasal intermittent positive pressure ventilation as post-extubation respiratory support in preterm infants: a Meta analysis by Hong-Ke Shi
CONCLUSIONS: Compared with NIPPV, NHFOV can effectively remove CO(2) and reduce the risk of reintubation, without increasing the incidence of complications such as BPD, air leak, nasal damage, PVL, and IVH, and therefore, it can be used as a sequential respiratory support mode for preterm infants after extubation.
Predicting Hearing aid Benefit Using Speech-Evoked Envelope Following Responses in Children With Hearing Loss by Vijayalakshmi Easwar
Electroencephalography could serve as an objective tool to evaluate hearing aid benefit in infants who are developmentally unable to participate in hearing tests. We investigated whether speech-evoked envelope following responses (EFRs), a type of electroencephalography-based measure, could predict improved audibility with the use of a hearing aid in children with mild-to-severe permanent, mainly sensorineural, hearing…
Genetic analyses of chr11p15.5 region identify MUC5AC–MUC5B associated with asthma-related phenotypes by Xingnan Li
Objective: Genome-wide association studies (GWASs) have identified single nucleotide polymorphisms (SNPs) in chr11p15.5 region associated with asthma and idiopathic interstitial pneumonias (IIPs). We sought to identify functional genes for asthma by combining SNPs and mRNA expression in bronchial epithelial cells (BEC) in the Severe Asthma Research Program (SARP). Methods: Correlation analyses of mRNA expression of…
Metastatic pheochromocytoma and paraganglioma: Somatostatin receptor 2 expression, genetics and therapeutic responses by Alessa Fischer
CONCLUSIONS: SSTR2 expression was independently associated with SDHB/SDHx mutations and metastatic disease. We confirm a high disease control rate of somatostatin receptor-based therapies in metastatic PPGLs.
Comparative evaluation between external jugular and internal jugular venous catheterization through landmark technique by Hitesh Khanna
CONCLUSION: Anaesthetists should rethink alternate routes for the insertion of central vein cannulation. The external jugular cannulation route is one of them.
Targeted therapies in advanced biliary tract cancers-a narrative review by Michael LaPelusa
CONCLUSIONS: Targeted agents can improve survival in patients with advanced BTCs and have substantially increased the number of potential therapeutic options in patients with refractory disease. The therapeutic landscape of targeted therapies for patients with advanced BTCs continues to evolve based on improvements in detection of genomic alterations.
A critical review of methotrexate clinical interactions: role of transporters by Fatemeh Jafari
INTRODUCTION: Methotrexate (MTX) is an anti-folate and immunosuppressive drug prescribed for various malignancies and immune diseases. However, delayed elimination of MTX associated with concomitant use of some medications can lead to severe and life-threatening adverse effects.
Frailty in community-dwelling older adults: reliability and validity of the Turkish version of the Gérontopôle frailty screening tool by Serdar Ceylan
BACKGROUND: Recognizing frailty had a great importance in countries with an increasing geriatric population. The study aims to evaluate the reliability and validation of the Gérontopôle frailty screening tool (GFST), which was developed to screen frailty in the community-dwelling older adults, for the Turkish population.
Low handgrip strength is associated with diabetic foot disease in geriatric patients with type 2 diabetes by Eren İmre
BACKGROUND: This study aims to reveal the prevalence of low handgrip strength in older patients with type 2 diabetes who have diabetic foot disease and to assess the association of handgrip strength with diabetic foot disease in older patients with type 2 diabetes.
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